Flunitrazolam Powder FNTZ Flunazolam Order Safely

What is Flunitrazolam Powder?

Flunitrazolam (FNTZ, Flunazolam) is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug.

And is a potent hypnotic and sedative drug similar to related compounds such as flunitrazepam, clonazolam and flubromazolam.

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It was first definitively identified and reported to the EMCDDA Early Warning System, by an analytical laboratory in Germany in October 2016, and had not been described in the scientific or patent literature before this.

It is the triazole analogue of Flunitrazepam (Rohypnol). The addition of the triazole ring to the scaffold increases potency significantly, this is evident as flunitrazolam is reported anecdotally to be active in the microgram level.

It is active at 0.1 mg

Flunitrazolam Powder is an analytical reference standard categorized as a benzodiazepine. Flunitrazolam has been found in biological samples from intoxication cases.

Preparation Methods

Chemical Synthesis of Flunitrazolam

This compound synthesis is based on modifications of benzodiazepine frameworks, incorporating a triazole ring and fluorophenyl substitution.

Although direct detailed synthetic routes for this compound are limited in public literature, analogous methods from related benzodiazepines and triazolobenzodiazepines provide insights into its preparation.

General Synthetic Strategy

Starting Materials : Typically, benzodiazepine intermediates with appropriate substitutions (e.g., 2-fluorophenyl groups) are used.

Cyclization and Functionalization : Introduction of the triazole ring is achieved via cyclization reactions involving hydrazine derivatives or similar reagents.

Oxidation and Reduction Steps : Key functional groups such as the nitro group undergo oxidation or reduction to achieve the desired chemical structure.

Analogous Benzodiazepine Intermediate Preparation (Based on Patent CN104130201B)
A related benzodiazepine thioketone intermediate preparation involves:

This method highlights the use of controlled temperature, solvent selection, and stoichiometric ratios to optimize yield and purity.

Oxidation and Reduction Reactions Relevant to this compound

Oxidation : The nitro group at position 7 can be oxidized to hydroxylamine or amine derivatives using reagents like potassium permanganate or enzymatic oxidation via cytochrome P450 enzymes (CYP3A4).

Reduction : The nitro group can be reduced to an amine via lithium aluminum hydride or catalytic hydrogenation, with yields ranging from 65% to over 80% depending on the method and conditions.