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Methylone (also known as “3,4-methylenedioxy-N-methylcathinone”, “MDMC”, “βk-MDMA” and by the slang term “M1”) is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes.

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What is MDMC or Methylone

MDMC, commonly called methylone, is an empathogen and stimulant psychoactive drug. MDMC may also refer to: Material Data Management Consortium, see Materials data management.

MDMC/EDMA, a psychedelic drug first synthesized by Alexander Shulgin.

MDMC Methylone (also known as “3,4-methylenedioxy-N-methylcathinone”, “MDMC”, “βk-MDMA” and by the slang term “M1”) is an empathogen and stimulant psychoactive drug.

It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes.

How to buy MDMC

Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone.

The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group.

Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant.

Methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries

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Methylone substitutes for MDMA in drug discrimination tests in rodents.

Methylone does not substitute for the stimulant amphetamine or for the hallucinogen DOM in animal drug discrimination tests.

Further, also in common with MDMA, methylone acts on monoaminergic systems.

In vitro, methylone has one third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.

In spite of these behavioral and pharmacological similarities between methylone and MDMA,

The observed subjective effects of both drugs are not completely identical. Alexander Shulgin wrote of the former:

“[Methylone] has almost the same potency of MDMA, but it does not produce the same effects.

It has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA.”

In acute pharmacological studies of methylone (50–300 mg) in humans, the drug produced physiological and psychological effects including increased blood pressure, heart rate, body temperature, pupil dilation, stimulation, euphoria, feelings of well-being, enhanced empathy, increased sociability, and altered perception.

The studies found that the effects of methylone were similar to or milder than those of MDMA.

Methylone had a faster onset of action and its subjective effects wore off sooner than MDMA, which might lead to a redosing pattern of use.

The misuse potential of methylone, as measured by for instance drug liking responses, appeared to be similar to that of MDMA.

However it also has less off-target effects than MDMA which may be an advantage for medical applications.

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