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What is 4-Chloromethcathinone

4-Chloromethcathinone (also known as 4-CMC and Clephedrone) is a stimulant drug of the cathinone class that has been sold online as a designer drug.
Sweden’s public health agency suggested classifying 4-Chloromethcathinone (klefedron) as illegal narcotic on June 1, 2015.

Also, the profile of effects of 4-CMC on the body depends on the route of administration; oral ingestion results in a euphoric effect, while snorting in a speed-like effect is accompanied by agitation, increased concentration, and increased self-confidence

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Short-term

4-CMC produces similar side effects to mephedrone, including: increased blood pressure, tachycardia, hyperthermia, and anxiety.

Neurotoxicity

Its chemical structure closely resembles para-chloromethamphetamine, raising concerns about its potential to readily induce cell death of serotoninergic neurons. However, no neurotoxicity of this kind has been found, but studies involving mice do indicate that it is neurotoxic through other mechanisms. 4-CMC is cytotoxic and induces oxidative stress.

 

 

Pharmacodynamics

Similar to mephedrone, 4-CMC mainly acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), and partially as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with similar potency